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Using whole exome sequencing to identify candidate genes with rare variants in nonsyndromic cleft lip and palate

INTRODUCTION: Studies suggest that nonsyndromic cleft lip and palate (NSCLP) is polygenic with variable penetrance, presenting a challenge in identifying all causal genetic variants. Despite relatively high prevalence of NSCLP among Amerindian populations, no large whole exome sequencing (WES) studi...

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Bibliografski detalji
Izdano u:Genet Epidemiol
Glavni autori: Aylward, Alana, Cai, Yi, Lee, Andrew, Blue, Elizabeth, Rabinowitz, Daniel, Haddad, Joseph
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985012/
https://ncbi.nlm.nih.gov/pubmed/27229527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21972
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