Single-Molecule Sequencing Reveals Complex Genome Variation of Hepatitis B Virus during 15 Years of Chronic Infection following Liver Transplantation

Chronic hepatitis B (CHB) is prevalent worldwide. The infectious agent, hepatitis B virus (HBV), replicates via an RNA intermediate and is error prone, leading to the rapid generation of closely related but not identical viral variants, including those that can escape host immune responses and antiv...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Betz-Stablein, B. D., Töpfer, A., Littlejohn, M., Yuen, L., Colledge, D., Sozzi, V., Angus, P., Thompson, A., Revill, P., Beerenwinkel, N., Warner, N., Luciani, F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Genetic Diversity and Evolution
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984637/
https://ncbi.nlm.nih.gov/pubmed/27252524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00243-16
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