Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children

One in 400 people has a maternally inherited mutation in mtDNA potentially causing incurable disease. In so-called heteroplasmic disease, mutant and normal mtDNA co-exist in the cells of carrier women. Disease severity depends on the proportion of inherited abnormal mtDNA molecules. Families who hav...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Biochem Soc Trans
Autori principali: Diot, Alan, Dombi, Eszter, Lodge, Tiffany, Liao, Chunyan, Morten, Karl, Carver, Janet, Wells, Dagan, Child, Tim, Johnston, Iain G., Williams, Suzannah, Poulton, Joanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2016
Soggetti:
Biochemical Society Focused Meetings
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984448/
https://ncbi.nlm.nih.gov/pubmed/27528757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20160095
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