Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity

Presynaptic activation of the diacylglycerol (DAG)/protein kinase C (PKC) pathway is a central event in short-term synaptic plasticity. Two substrates, Munc13-1 and Munc18-1, are essential for DAG-induced potentiation of vesicle priming, but the role of most presynaptic PKC substrates is not underst...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: de Jong, Arthur P. H., Meijer, Marieke, Saarloos, Ingrid, Cornelisse, Lennart Niels, Toonen, Ruud F. G., Sørensen, Jakob B., Verhage, Matthijs
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983831/
https://ncbi.nlm.nih.gov/pubmed/27091977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522927113
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