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Antibiotic treatment enhances the genome-wide mutation rate of target cells

Although it is well known that microbial populations can respond adaptively to challenges from antibiotics, empirical difficulties in distinguishing the roles of de novo mutation and natural selection have left several issues unresolved. Here, we explore the mutational properties of Escherichia coli...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Long, Hongan, Miller, Samuel F., Strauss, Chloe, Zhao, Chaoxian, Cheng, Lei, Ye, Zhiqiang, Griffin, Katherine, Te, Ronald, Lee, Heewook, Chen, Chi-Chun, Lynch, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983809/
https://ncbi.nlm.nih.gov/pubmed/27091991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601208113
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