Mitochondrial-Targeting MET Kinase Inhibitor Kills Erlotinib-Resistant Lung Cancer Cells

[Image: see text] Lung cancer cells harboring activating EGFR mutations acquire resistance to EGFR tyrosine kinase inhibitors (TKIs) by activating several bypass mechanisms, including MET amplification and overexpression. We show that a significant proportion of activated MET protein in EGFR TKI-res...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Yang, Tianming, Ng, Wai Har, Chen, Huan, Chomchopbun, Kamon, Huynh, The Hung, Go, Mei Lin, Kon, Oi Lian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2016
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983733/
https://ncbi.nlm.nih.gov/pubmed/27563407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00223
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