Quantitative Proteomics Discloses MET Expression in Mitochondria as a Direct Target of MET Kinase Inhibitor in Cancer Cells

Cancer cells with MET overexpression are paradoxically more sensitive to MET inhibition than cells with baseline MET expression. The underlying molecular mechanisms are incompletely understood. Here, we have traced early responses of SNU5, a MET-overexpressing gastric cancer cell line, exposed to su...

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Detalhes bibliográficos
Main Authors: Guo, Tiannan, Zhu, Yi, Gan, Chee Sian, Lee, Sze Sing, Zhu, Jiang, Wang, Haixia, Li, Xin, Christensen, James, Huang, Shiang, Kon, Oi Lian, Sze, Siu Kwan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101852/
https://ncbi.nlm.nih.gov/pubmed/20713453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M110.001776
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