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Calcineurin β protects brain after injury by activating the unfolded protein response

The Ca(2+)-dependent phosphatase, calcineurin (CN) is thought to play a detrimental role in damaged neurons; however, its role in astrocytes is unclear. In cultured astrocytes, CNβ expression increased after treatment with a sarco/endoplasmic reticulum Ca(2+)-ATPase inhibitor, thapsigargin, and with...

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Bibliografiske detaljer
Udgivet i:Neurobiol Dis
Main Authors: Chen, Yanan, Holstein, Deborah M., Aime, Sofia, Bollo, Mariana, Lechleiter, James D.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983525/
https://ncbi.nlm.nih.gov/pubmed/27334877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.06.011
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