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Bidirectional homeostatic regulation of a depression-related brain state by GABAergic deficits and ketamine treatment

BACKGROUND: Major depressive disorder (MDD) is increasingly recognized to involve functional deficits in both GABAergic and glutamatergic synaptic transmission. To elucidate the relationship between these phenotypes we made use of GABA(A) receptor γ2 subunit heterozygous (γ2(+/−)) mice, which we pre...

詳細記述

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書誌詳細
出版年:Biol Psychiatry
主要な著者: Ren, Zhen, Pribiag, Horia, Jefferson, Sarah J., Shorey, Matthew, Fuchs, Thomas, Stellwagen, David, Luscher, Bernhard
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983262/
https://ncbi.nlm.nih.gov/pubmed/27062563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2016.02.009
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