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Bidirectional homeostatic regulation of a depression-related brain state by GABAergic deficits and ketamine treatment

BACKGROUND: Major depressive disorder (MDD) is increasingly recognized to involve functional deficits in both GABAergic and glutamatergic synaptic transmission. To elucidate the relationship between these phenotypes we made use of GABA(A) receptor γ2 subunit heterozygous (γ2(+/−)) mice, which we pre...

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Vydáno v:Biol Psychiatry
Hlavní autoři: Ren, Zhen, Pribiag, Horia, Jefferson, Sarah J., Shorey, Matthew, Fuchs, Thomas, Stellwagen, David, Luscher, Bernhard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983262/
https://ncbi.nlm.nih.gov/pubmed/27062563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2016.02.009
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