Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency

Embryonic stem cells (ESCs) are cell lines derived from the mammalian pre-implantation embryo. Here we assess the impact of derivation and culture conditions on both functional potency and ESC transcriptional identity. Individual ESCs cultured in either two small-molecule inhibitors (2i) or with kno...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Martin Gonzalez, Javier, Morgani, Sophie M., Bone, Robert A., Bonderup, Kasper, Abelchian, Sahar, Brakebusch, Cord, Brickman, Joshua M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983099/
https://ncbi.nlm.nih.gov/pubmed/27509134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.07.009
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