A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis

BACKGROUND: In the absence of a validated animal model and/or an immune correlate which predict vaccine-mediated protection, large-scale clinical trials are currently the only option to prove efficacy of new tuberculosis candidate vaccines. Tools to facilitate testing of new tuberculosis (TB) vaccin...

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Pubblicato in:BMC Infect Dis
Autori principali: Zelmer, Andrea, Tanner, Rachel, Stylianou, Elena, Damelang, Timon, Morris, Sheldon, Izzo, Angelo, Williams, Ann, Sharpe, Sally, Pepponi, Ilaria, Walker, Barry, Hokey, David A., McShane, Helen, Brennan, Michael, Fletcher, Helen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983071/
https://ncbi.nlm.nih.gov/pubmed/27519524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-016-1751-4
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