Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo

Tissue inhibitor of metalloproteinases-3 (TIMP-3) regulates extracellular matrix via its inhibition of matrix metalloproteinases and membrane-bound sheddases. Timp-3 is expressed at multiple sites of extensive tissue remodelling. This extends to bone where its role, however, remains largely unresolv...

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Udgivet i:PLoS One
Main Authors: Javaheri, Behzad, Hopkinson, Mark, Poulet, Blandine, Pollard, Andrea S., Shefelbine, Sandra J., Chang, Yu-Mei, Francis-West, Philippa, Bou-Gharios, George, Pitsillides, Andrew A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982603/
https://ncbi.nlm.nih.gov/pubmed/27519049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159657
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