Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity

Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme family in mice results in important joint and bone abnormalities, suggesting a role in skeletal development. As such, the cont...

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Vydáno v:PLoS One
Hlavní autoři: Poulet, Blandine, Liu, Ke, Plumb, Darren, Vo, Phoung, Shah, Mittal, Staines, Katherine, Sampson, Alexandra, Nakamura, Hiroyuki, Nagase, Hideaki, Carriero, Alessandra, Shefelbine, Sandra, Pitsillides, Andrew A., Bou-Gharios, George
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176305/
https://ncbi.nlm.nih.gov/pubmed/28002442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167971
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