Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and Depletion

Tryptophan (Trp) metabolism via the kynurenine pathway (KP) was assessed in normal healthy US volunteers at baseline and after acute Trp depletion (ATD) and acute Trp loading (ATL) using amino acid formulations. The hepatic KP accounts for ~90% of overall Trp degradation. Liver Trp 2,3-dioxygenase (...

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Detalles Bibliográficos
Publicado en:Int J Tryptophan Res
Main Authors: Badawy, Abdulla A.-B., Dougherty, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado: Libertas Academica 2016
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981220/
https://ncbi.nlm.nih.gov/pubmed/27547036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/IJTR.S38189
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