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Mechanisms of the Pellagragenic Effect of Leucine: Stimulation of Hepatic Tryptophan Oxidation by Administration of Branched-Chain Amino Acids to Healthy Human Volunteers and the Role of Plasma Free Tryptophan and Total Kynurenines

The pellagragenic effect of leucine (Leu) has been proposed to involve modulation of L-tryptophan (Trp) metabolism along the hepatic kynurenine pathway. Here, we discuss some of the mechanisms suggested and report the effects in healthy volunteers of single doses of Leu (4.05–6.75 g) administered in...

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書誌詳細
出版年:Int J Tryptophan Res
主要な著者: Badawy, Abdulla A-B, Lake, Sarah L, Dougherty, Donald M
フォーマット: Artigo
言語:Inglês
出版事項: Libertas Academica 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259507/
https://ncbi.nlm.nih.gov/pubmed/25520560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/IJTR.S18231
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