A recellularized human colon model identifies cancer driver genes

Refined cancer models are needed to bridge the gap between cell-line, animal and clinical research. Here we describe the engineering of an organotypic colon cancer model by recellularization of a native human matrix that contains cell-populated mucosa and an intact muscularis mucosa layer. This ex v...

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Vydáno v:Nat Biotechnol
Hlavní autoři: Chen, Huanhuan Joyce, Wei, Zhubo, Sun, Jian, Bhattacharya, Asmita, Savage, David J, Serda, Rita, Mackeyev, Yuri, Curley, Steven A., Bu, Pengcheng, Wang, Lihua, Chen, Shuibing, Cohen-Gould, Leona, Huang, Emina, Shen, Xiling, Lipkin, Steven M., Copeland, Neal G., Jenkins, Nancy A., Shuler, Michael L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980997/
https://ncbi.nlm.nih.gov/pubmed/27398792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3586
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