Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment

The cardiac microenvironment includes cardiomyocytes, fibroblasts and macrophages, which regulate remodeling after myocardial infarction (MI). Targeting this microenvironment is a novel therapeutic approach for MI. We found that the natural compound derivative, BIO ((2′Z,3′E)-6-Bromoindirubin-3′-oxi...

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Vydáno v:Sci Rep
Hlavní autoři: Kim, Yong Sook, Jeong, Hye-yun, Kim, Ah Ra, Kim, Woong-Hee, Cho, Haaglim, Um, JungIn, Seo, Youngha, Kang, Wan Seok, Jin, Suk-Won, Kim, Min Chul, Kim, Yong-Chul, Jung, Da-Woon, Williams, Darren R., Ahn, Youngkeun
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980696/
https://ncbi.nlm.nih.gov/pubmed/27510556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30726
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