Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment

The cardiac microenvironment includes cardiomyocytes, fibroblasts and macrophages, which regulate remodeling after myocardial infarction (MI). Targeting this microenvironment is a novel therapeutic approach for MI. We found that the natural compound derivative, BIO ((2′Z,3′E)-6-Bromoindirubin-3′-oxi...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Kim, Yong Sook, Jeong, Hye-yun, Kim, Ah Ra, Kim, Woong-Hee, Cho, Haaglim, Um, JungIn, Seo, Youngha, Kang, Wan Seok, Jin, Suk-Won, Kim, Min Chul, Kim, Yong-Chul, Jung, Da-Woon, Williams, Darren R., Ahn, Youngkeun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980696/
https://ncbi.nlm.nih.gov/pubmed/27510556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30726
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