Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I

Hereditary tyrosinemia type I (HT1) is caused by a deficiency in the enzyme fumarylacetoacetate hydrolase (Fah). Fah-deficient mice and pigs are phenotypically analogous to human HT1, but do not recapitulate all the chronic features of the human disorder, especially liver fibrosis and cirrhosis. Rat...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhang, Ludi, Shao, Yanjiao, Li, Lu, Tian, Feng, Cen, Jin, Chen, Xiaotao, Hu, Dan, Zhou, Yan, Xie, Weifen, Zheng, Yunwen, Ji, Yuan, Liu, Mingyao, Li, Dali, Hui, Lijian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980609/
https://ncbi.nlm.nih.gov/pubmed/27510266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31460
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