Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency

Mitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of diseases includes serious or fatal neurological presentations such as Leigh syndrome and there are very limited evidence-based treatment opti...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ehinger, Johannes K., Piel, Sarah, Ford, Rhonan, Karlsson, Michael, Sjövall, Fredrik, Frostner, Eleonor Åsander, Morota, Saori, Taylor, Robert W., Turnbull, Doug M., Cornell, Clive, Moss, Steven J., Metzsch, Carsten, Hansson, Magnus J., Fliri, Hans, Elmér, Eskil
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980488/
https://ncbi.nlm.nih.gov/pubmed/27502960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12317
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