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T-type calcium channel regulation of neural tube closure and EphrinA/EPHA expression

A major class of human birth defects arise from aberrations during neural tube closure (NTC). We report on a NTC signaling pathway requiring T-type calcium channels (TTCC) that is conserved between primitive chordates (Ciona) and Xenopus. With loss of TTCCs there is a failure to seal the anterior ne...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Abdul-Wajid, Sarah, Morales-Diaz, Heidi, Khairallah, Stephanie M., Smith, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980084/
https://ncbi.nlm.nih.gov/pubmed/26489462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.035
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