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The big bang of genome editing technology: development and application of the CRISPR/Cas9 system in disease animal models

Targeted genome editing technology has been widely used in biomedical studies. The CRISPR-associated RNA-guided endonuclease Cas9 has become a versatile genome editing tool. The CRISPR/Cas9 system is useful for studying gene function through efficient knock-out, knock-in or chromatin modification of...

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Detalhes bibliográficos
Publicado no:Dongwuxue Yanjiu
Main Authors: SHAO, Ming, XU, Tian-Rui, CHEN, Ce-Shi
Formato: Artigo
Idioma:Inglês
Publicado em: Science Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980067/
https://ncbi.nlm.nih.gov/pubmed/27469250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.13918/j.issn.2095-8137.2016.4.191
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