Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Although mitochondrial DNA has been implicated in diseases such as cancer, its role remains to be defined. Using three models of tumorigenesis, namely glioblastoma multiforme, multiple myeloma and osteosarcoma, we show that mitochondrial DNA plays defining roles at early and late tumour progression....

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Lee, W T Y, Cain, J E, Cuddihy, A, Johnson, J, Dickinson, A, Yeung, K-Y, Kumar, B, Johns, T G, Watkins, D N, Spencer, A, St John, J C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979526/
https://ncbi.nlm.nih.gov/pubmed/27551510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2016.16
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