Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain disease

Expanding on a quinazoline scaffold, we developed tricyclic compounds with biological activity. These compounds bind to the 18 kDa translocator protein (TSPO) and protect U118MG (glioblastoma cell line of glial origin) cells from glutamate-induced cell death. Fascinating, they can induce neuronal di...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cell Death Discov
Main Authors: Vainshtein, A, Veenman, L, Shterenberg, A, Singh, S, Masarwa, A, Dutta, B, Island, B, Tsoglin, E, Levin, E, Leschiner, S, Maniv, I, Pe’er, L, Otradnov, I, Zubedat, S, Aga-Mizrachi, S, Weizman, A, Avital, A, Marek, I, Gavish, M
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2015
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979516/
https://ncbi.nlm.nih.gov/pubmed/27551459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.27
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