Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells

Autophagy has been linked to the regulation of both the prevention and progression of cancer. IFN-γ has been shown to induce autophagy in multiple cell lines in vitro. However, whether IFN-γ can induce autophagy and whether autophagy promotes malignant transformation in healthy lactating bovine mamm...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Xia, X-j, Gao, Y-y, Zhang, J, Wang, L, Zhao, S, Che, Y-y, Ao, C-j, Yang, H-j, Wang, J-q, Lei, L-c
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979444/
https://ncbi.nlm.nih.gov/pubmed/27551491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.65
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