Efficacy of PARP inhibition in Pde6a mutant mouse models for retinitis pigmentosa depends on the quality and composition of individual human mutations

Retinitis pigmentosa (RP), an inherited blinding disease, is caused by a variety of different mutations that affect retinal photoreceptor function and survival. So far there is neither effective treatment nor cure. We have previously shown that poly(ADP-ribose)polymerase (PARP) acts as a common and...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Discov
Egile Nagusiak: Jiao, K, Sahaboglu, A, Zrenner, E, Ueffing, M, Ekström, P A R, Paquet-Durand, F
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979439/
https://ncbi.nlm.nih.gov/pubmed/27551530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2016.40
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