Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β(2)-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase–Knockout Mice

Mice lacking the endogenous β(2)-adrenoceptor (β(2)AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an “asthma-like” phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of β(2)AR agonists t...

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Detalles Bibliográficos
Publicado en:Am J Respir Cell Mol Biol
Main Authors: Forkuo, Gloria S., Kim, Hosu, Thanawala, Vaidehi J., Al-Sawalha, Nour, Valdez, Daniel, Joshi, Radhika, Parra, Sergio, Pera, Tonio, Gonnella, Patricia A., Knoll, Brian J., Walker, Julia K. L., Penn, Raymond B., Bond, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2016
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979368/
https://ncbi.nlm.nih.gov/pubmed/26909542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0373OC
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