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hotspot: software to support sperm-typing for investigating recombination hotspots

Motivation: In many organisms, including humans, recombination clusters within recombination hotspots. The standard method for de novo detection of recombinants at hotspots is sperm typing. This relies on allele-specific PCR at single nucleotide polymorphisms. Designing allele-specific primers by ha...

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Publicat a:Bioinformatics
Autors principals: Odenthal-Hesse, Linda, Dutheil, Julien Y., Klötzl, Fabian, Haubold, Bernhard
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978934/
https://ncbi.nlm.nih.gov/pubmed/27153632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw195
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