Interferon Regulatory Factor-1 Mediates Alveolar Macrophage Pyroptosis During LPS-Induced Acute Lung Injury in Mice

Previously, we demonstrated that pyroptosis in alveolar macrophages (AMs) plays an essential role in lipopolysaccharide (LPS)-induced acute lung injury. However, the underlying mechanism remains largely unclear. Here, we show that the absence of interferon regulatory factor 1 (IRF-1) in genetic knoc...

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Bibliografske podrobnosti
izdano v:Shock
Main Authors: Wu, Dongdong, Pan, Pinhua, Su, Xiaoli, Zhang, Lemeng, Qin, Qingwu, Tan, Hongyi, Huang, Li, Li, Yuanyuan
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2016
Teme:
Basic Science Aspects
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978602/
https://ncbi.nlm.nih.gov/pubmed/26939040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000595
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