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Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase

Phospholipid flippases in the type IV P-type ATPase (P4-ATPases) family establish membrane asymmetry and play critical roles in vesicular transport, cell polarity, signal transduction, and neurologic development. All characterized P4-ATPases flip glycerophospholipids across the bilayer to the cytoso...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Roland, Bartholomew P., Graham, Todd R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978280/
https://ncbi.nlm.nih.gov/pubmed/27432949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525730113
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