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Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21

A detailed understanding of the molecular mechanisms whereby ubiquitin (Ub) recognizes enzymes in the Ub proteasome system is crucial for understanding the biological function of Ub. Many structures of Ub complexes have been solved and, in most cases, reveal a large structural epitope on a common fa...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Leung, Isabel, Dekel, Ayelet, Shifman, Julia M., Sidhu, Sachdev S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978272/
https://ncbi.nlm.nih.gov/pubmed/27436899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524648113
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