Anti‐angiogenic effects of novel cyclin‐dependent kinase inhibitors with a pyrazolo[4,3‐d]pyrimidine scaffold

BACKGROUND AND PURPOSE: Cyclin‐dependent kinase 5 (CDK5) has recently emerged as an attractive target in several tumour entities. Inhibition of CDK5 has been shown to have anti‐angiogenic effects in vitro and in vivo. However, potent inhibitors of CDK5, which can be applied in vivo, are still scarce...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Zhang, S, Ulrich, M, Gromnicka, A, Havlíček, L, Kryštof, V, Jorda, R, Strnad, M, Vollmar, A M, Zahler, S
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978162/
https://ncbi.nlm.nih.gov/pubmed/27390037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13546
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