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Anti‐angiogenic effects of novel cyclin‐dependent kinase inhibitors with a pyrazolo[4,3‐d]pyrimidine scaffold

BACKGROUND AND PURPOSE: Cyclin‐dependent kinase 5 (CDK5) has recently emerged as an attractive target in several tumour entities. Inhibition of CDK5 has been shown to have anti‐angiogenic effects in vitro and in vivo. However, potent inhibitors of CDK5, which can be applied in vivo, are still scarce...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Zhang, S, Ulrich, M, Gromnicka, A, Havlíček, L, Kryštof, V, Jorda, R, Strnad, M, Vollmar, A M, Zahler, S
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978162/
https://ncbi.nlm.nih.gov/pubmed/27390037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13546
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