DNA methylation on N(6)-adenine in mammalian embryonic stem cells

It has been widely accepted that 5-methylcytosine is the only form of DNA methylation in mammalian genomes. Here we identify N(6)-methyladenine as another form of DNA modification in mouse embryonic stem cells. Alkbh1 encodes a demethylase for N(6)-methyladenine. An increase of N(6)-methyladenine le...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Wu, Tao P., Wang, Tao, Seetin, Matthew G., Lai, Yongquan, Zhu, Shijia, Lin, Kaixuan, Liu, Yifei, Byrum, Stephanie D., Mackintosh, Samuel G., Zhong, Mei, Tackett, Alan, Wang, Guilin, Hon, Lawrence S., Fang, Gang, Swenberg, James A., Xiao, Andrew Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977844/
https://ncbi.nlm.nih.gov/pubmed/27027282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17640
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