Echinocandin B biosynthesis: a biosynthetic cluster from Aspergillus nidulans NRRL 8112 and reassembly of the subclusters Ecd and Hty from Aspergillus pachycristatus NRRL 11440 reveals a single coherent gene cluster

BACKGROUND: Echinocandins are nonribosomal lipopeptides produced by ascommycete fungi. Due to their strong inhibitory effect on fungal cell wall biosynthesis and lack of human toxicity, they have been developed to an important class of antifungal drugs. Since 2012, the biosynthetic gene clusters of...

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Библиографические подробности
Опубликовано в: :BMC Genomics
Главные авторы: Hüttel, Wolfgang, Youssar, Loubna, Grüning, Björn A., Günther, Stefan, Hugentobler, Katharina G.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977696/
https://ncbi.nlm.nih.gov/pubmed/27502607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-2885-x
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