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Identification and Characterization of the Echinocandin B Biosynthetic Gene Cluster from Emericella rugulosa NRRL 11440

Echinocandins are a family of fungal lipidated cyclic hexapeptide natural products. Due to their effectiveness as antifungal agents, three semisynthetic derivatives have been developed and approved for treatment of human invasive candidiasis. All six of the amino acid residues are hydroxylated, incl...

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Autores principales: Cacho, Ralph A., Jiang, Wei, Chooi, Yit-Heng, Walsh, Christopher T., Tang, Yi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482383/
https://ncbi.nlm.nih.gov/pubmed/22998630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307220z
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