Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

T cells undergo profound metabolic changes to meet the increased energy demands of maintaining an antiviral response. We postulated that differences in metabolic reprogramming would shape the efficacy of CD8 T cells mounted against persistent viral infections. We found that the poorly functional PD-...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Schurich, Anna, Pallett, Laura J., Jajbhay, Danyal, Wijngaarden, Jessica, Otano, Itziar, Gill, Upkar S., Hansi, Navjyot, Kennedy, Patrick T., Nastouli, Eleni, Gilson, Richard, Frezza, Christian, Henson, Sian M., Maini, Mala K.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2016
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977274/
https://ncbi.nlm.nih.gov/pubmed/27452473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.078
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