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ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae.

Saccharomyces cerevisiae translation initiation factor eIF-4A, an RNA helicase of the Asp-Glu-Ala-Asp (DEAD) box protein family, was mutated in the putative ATP binding site and expressed in Escherichia coli. Mutant proteins with alanine at position 66 replaced by glycine [eIF-4A(A66G)] or valine [e...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Blum, S, Schmid, S R, Pause, A, Buser, P, Linder, P, Sonenberg, N, Trachsel, H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49771/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1502180/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.16.7664
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