Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours

Tumour cells fulfil the bioenergetic and biosynthetic needs of proliferation using the available environmental metabolites. Metabolic adaptation to hypoxia causes decreased mitochondrial function and increased lactate production. This work examines the biological importance of the hypoxia-inducible...

全面介紹

Na minha lista:
書目詳細資料
發表在:Sci Rep
Main Authors: Golias, Tereza, Papandreou, Ioanna, Sun, Ramon, Kumar, Bhavna, Brown, Nicole V., Swanson, Benjamin J., Pai, Reetesh, Jaitin, Diego, Le, Quynh-Thu, Teknos, Theodoros N., Denko, Nicholas C.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976358/
https://ncbi.nlm.nih.gov/pubmed/27498883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31146
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍