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Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Co-activator Recruitment
The transcription factor retinoid acid-related orphan receptor gamma t (RORγt) directs the differentiation of T helper 17 (Th17) cells. Th17 cells mediate pathological immune responses responsible for autoimmune diseases, including psoriasis and multiple sclerosis. Previous studies have focused on R...
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| Veröffentlicht in: | J Immunol |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4976012/ https://ncbi.nlm.nih.gov/pubmed/27430721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600548 |
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