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Strain Mediated Adaptation Is Key for Myosin Mechanochemistry: Discovering General Rules for Motor Activity

A structure-based model of myosin motor is built in the same spirit of our early work for kinesin-1 and Ncd towards physical understanding of its mechanochemical cycle. We find a structural adaptation of the motor head domain in post-powerstroke state that signals faster ADP release from it compared...

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Veröffentlicht in:PLoS Comput Biol
Hauptverfasser: Jana, Biman, Onuchic, José N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975490/
https://ncbi.nlm.nih.gov/pubmed/27494025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005035
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