Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile

Despite being a conceptually appealing alternative to conventional antibiotics, a major challenge toward the successful implementation of antisense treatments for bacterial infections is the development of efficient oligonucleotide delivery systems. Cationic vesicles (bolasomes) composed of dequalin...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Nanomedicine
Hauptverfasser: Hegarty, John P, Krzeminski, Jacek, Sharma, Arun K, Guzman-Villanueva, Diana, Weissig, Volkmar, Stewart, David B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975145/
https://ncbi.nlm.nih.gov/pubmed/27536102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S109600
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