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Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, representing approximately 75% of all renal neoplasms. ccRCC is known to be strongly associated with silencing of the von Hippel Lindau (VHL) tumor suppressor gene, yet VHL deficiency alone does not seem to be suffi...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Johansson, Elinn, Rönö, Birgitte, Johansson, Martin, Lindgren, David, Möller, Christina, Axelson, Håkan, Smith, Emma M. K.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974510/
https://ncbi.nlm.nih.gov/pubmed/27491826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30739
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