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Dual Function of Phosphoubiquitin in E3 Activation of Parkin
Mutations in the gene encoding parkin, an auto-inhibited E3 ubiquitin ligase that functions in the clearance of damaged mitochondria, are the most common cause of autosomal recessive juvenile Parkinsonism. The mechanism regulating parkin activation remains poorly understood. Here we show, by using i...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4974400/ https://ncbi.nlm.nih.gov/pubmed/27284007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.728600 |
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