The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria

Copper-transporting ATPase ATP7A is essential for mammalian copper homeostasis. Loss of ATP7A activity is associated with fatal Menkes disease and various other pathologies. In cells, ATP7A inactivation disrupts copper transport from the cytosol into the secretory pathway. Using fibroblasts from Men...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bhattacharjee, Ashima, Yang, Haojun, Duffy, Megan, Robinson, Emily, Conrad-Antoville, Arianrhod, Lu, Ya-Wen, Capps, Tony, Braiterman, Lelita, Wolfgang, Michael, Murphy, Michael P., Yi, Ling, Kaler, Stephen G., Lutsenko, Svetlana, Ralle, Martina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974379/
https://ncbi.nlm.nih.gov/pubmed/27226607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.727248
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