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Unbiased estimation of biomarker panel performance when combining training and testing data in a group sequential design

Motivated by an ongoing study to develop a screening test able to identify patients with undiagnosed Sjögren’s Syndrome in a symptomatic population, we propose methodology to combine multiple biomarkers and evaluate their performance in a two-stage group sequential design that proceeds as follows: b...

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Bibliografski detalji
Izdano u:Biometrics
Glavni autori: Tayob, Nabihah, Do, Kim-Anh, Feng, Ziding
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974170/
https://ncbi.nlm.nih.gov/pubmed/26845527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/biom.12480
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