Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2

Genome-wide association studies have revealed several common genetic risk variants for ulcerative colitis (UC). However, little is known about the contribution of rare, large effect genetic variants to UC susceptibility. In this study, we performed a deep targeted re-sequencing of 122 genes in Dutch...

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Udgivet i:PLoS One
Main Authors: Visschedijk, Marijn C., Alberts, Rudi, Mucha, Soren, Deelen, Patrick, de Jong, Dirk J., Pierik, Marieke, Spekhorst, Lieke M., Imhann, Floris, van der Meulen-de Jong, Andrea E., van der Woude, C. Janneke, van Bodegraven, Adriaan A., Oldenburg, Bas, Löwenberg, Mark, Dijkstra, Gerard, Ellinghaus, David, Schreiber, Stefan, Wijmenga, Cisca, Rivas, Manuel A., Franke, Andre, van Diemen, Cleo C., Weersma, Rinse K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973970/
https://ncbi.nlm.nih.gov/pubmed/27490946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159609
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