Cytochrome P450 1B1 Contributes to the Development of Angiotensin II–Induced Aortic Aneurysm in Male Apoe(−/−) Mice

Cytochrome P450 (CYP) 1B1 is implicated in vascular smooth muscle cell migration, proliferation, and hypertension. We assessed the contribution of CYP1B1 to angiotensin (Ang) II–induced abdominal aortic aneurysm (AAA). Male Apoe(−/−)/Cyp1b1(+/+) and Apoe(−/−)/Cyp1b1(−/−) mice were infused with Ang I...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Thirunavukkarasu, Shyamala, Khan, Nayaab S., Song, Chi Young, Ghafoor, Hafiz U., Brand, David D., Gonzalez, Frank J., Malik, Kafait U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2016
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973656/
https://ncbi.nlm.nih.gov/pubmed/27301358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.04.005
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