Protective Efficacy Induced by Genetically Attenuated Mid-to-Late Liver-Stage Arresting Plasmodium berghei Δmrp2 Parasites

Whole parasite immunization strategies employing genetically attenuated parasites (GAP), which arrest during liver-stage development, have been applied successfully for induction of sterile malaria protection in rodents. Recently, we generated a Plasmodium berghei GAP-lacking expression of multidrug...

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Udgivet i:Am J Trop Med Hyg
Main Authors: van der Velden, Maarten, Rijpma, Sanna R., Verweij, Vivienne, van Gemert, Geert-Jan, Chevalley-Maurel, Séverine, van de Vegte-Bolmer, Marga, Franke-Fayard, Blandine M., Russel, Frans G. M., Janse, Chris J., Sauerwein, Robert W., Koenderink, Jan B.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Tropical Medicine and Hygiene 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973185/
https://ncbi.nlm.nih.gov/pubmed/27296385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.16-0226
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