Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients

BACKGROUND: In synovial sarcomas alterations in the cyclin D1-CDK4/6-Rb axis have been described. Also, β-catenin, a cyclin D1 regulator, is often overexpressed. Additionally, studies have shown that the t(X;18) translocation influences tumor behavior partly through cyclin D1 activation. We investig...

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Vydáno v:Ann Surg Oncol
Hlavní autoři: Vlenterie, Myrella, Hillebrandt-Roeffen, Melissa H. S., Schaars, Esther W. M., Flucke, Uta E., Fleuren, Emmy D. G., Navis, Anna C., Leenders, William P. J., Versleijen-Jonkers, Yvonne M. H., van der Graaf, Winette T. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2016
Témata:
Bone and Soft Tissue Sarcomas
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972869/
https://ncbi.nlm.nih.gov/pubmed/27334220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-016-5341-x
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